Java plum (Syzygium Cumini) leaves as a potential inhibitor of SARS-CoV-2 3- Chymotrypsine-Like Protease (3CLpro)

The 3-Chymotrypsine-Like Protease (3CLpro) is an enzyme that has a major function in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) life cycle. It can be utilized s protein target search for new medications. Herbal plants are expected to have contributions prevention and treatment of 2019 Corona Virus Disease (COVID-19), as many herbal might strong affinity 3CLpro COVID-19. purpose this study examine inhibitory activity, pytochemical components, antioxidant extracts from nine extracted by Ultrasound Assisted Extraction (UAE) method potential inhibit recombinant SARS-CoV-2 using vitro result, it used find novel medication candidates COVID-19 therapy. Determining activity DPPH ABTS method, total polyphenol flavonoid content Folin Ciocalteu quercetin method. From tested, Java Plum leaves (Syzygium cumini) had most active with value (IC50 = 226 μg/ml) 413±1.83 mg GAE/g extract 12.091±0.037 QE/g extract. Measurement obtained IC50 3.751 ± 0.0149 μg/ml, gives 4.43±0.06μg/ml. This suggests could source anti-COVID.